TY - JOUR
AU - BODMER, W. F.
AB - POSSIBLE evolutionary homology between the genetic regions controlling histocompatibility antigens (such as HL-A in man and H-2 in the mouse) and immunoglobulins has been proposed1,2. Recent studies involving β
2-microglobulin (β
2m) seem to support this idea. Human β
2m was found originally in the urine of patients with renal tubular dysfunction. It is also present in serum and on the surface of most types of cell3,4. It has a molecular weight of about 12,000 and shows substantial sequence homology with the constant region domains of immunoglobulin heavy chains5,6. Partially purified papain7,8 and detergent9 solubilised HL-A molecules, and H-2 molecules10, consist of two chains one of which is invariant and has been identified as β
2m11–13. Chance association during the isolation procedure has been shown to be unlikely by the cocapping on the cell surface of β
2m with the allogeneic chain of HL-A that carries the usual serologically detected determinants14–16.
TI - The β2-microglobulin gene is on chromosome 15 and not in the HL-A region
JF - Nature
DO - 10.1038/254267a0
DA - 1975-03-20
UR - https://www.deepdyve.com/lp/springer-journals/the-2-microglobulin-gene-is-on-chromosome-15-and-not-in-the-hl-a-CIVSTsYgpu
SP - 267
EP - 269
VL - 254
IS - 5497
DP - DeepDyve
ER -