TY - JOUR
AU - Bai, Jin
AB - INTRODUCTIONYY1, also known as ∂ transcription factor, nuclear factor‐E1 (NF‐E1), INO80 complex subunit S and upstream control region binding protein, was first discovered in the early 1990s by several independent research groups.1–5 It was initially identified as a transcriptional repressor of adeno‐associated virus (AAV) P5 promoter. And then, its repression function was found to be reversed by adenovirus E1A oncoprotein and manifest as a transcription activator subsequently. Due to its dual transcriptional activity, the protein was named as Yin Yang‐1 (YY1) from the Chinese word “Yin” for repression and “Yang” for activation. Now, it is generally accepted that YY1 is ubiquitously expressed in human tissues to modulate the expression of various genes and cellular mechanisms including DNA repair, transcriptional regulation and epigenetic modifications. Meanwhile, YY1 may also be autoregulated via its own binding sites.6 The maintenance of proper YY1 expression level plays an important role in the normal function of cells and organisms.Colorectal cancer (CRC) ranks third in incidence and second in mortality globally. International agency for research on cancer estimated more than 1.9 million new cases and 935,000 deaths in 2020, accounting for about one‐tenth of the total number of cancer cases and deaths.7 Patients who undergo radical 
TI - The role of transcription factor Yin Yang‐1 in colorectal cancer
JF - Cancer Medicine
DO - 10.1002/cam4.5745
DA - 2023-05-01
UR - https://www.deepdyve.com/lp/wiley/the-role-of-transcription-factor-yin-yang-1-in-colorectal-cancer-C9mQGF0eoW
SP - 11177
EP - 11190
VL - 12
IS - 10
DP - DeepDyve
ER -