TY - JOUR
AU - Rix, T E
AB - Sir Latchford et al. have reviewed 10 years experience of the surgical management of desmoid tumours in patients with FAP, with good results for 20 of their 143 patients who required an operation. They have mentioned the 120 patients who did not come to surgery, but they have omitted to include the outcomes for this group. In constructing their algorithm for the treatment of desmoids in FAP, they have included a recommendation to start patients on sulindac and/or tamoxifen, although the case for these drugs in desmoid disease is unproven. A recent article by Hansman et al.1 has shown that 10 of 13 patients had desmoids which did not progress when on this combination of drugs in high doses. Close inspection of this paper (which had no control group) will show how weak the evidence is for using these drugs, which both cause significant side-effects, in desmoid disease. A review from the Cleveland Clinic demonstrated that 10 per cent of desmoids can be expected to resolve spontaneously, with 80 per cent undergoing a cycle of growth and regression without any intervention being required. Were the 120 patients managed conservatively at St Mark's treated according to this algorithm? References 1 Hansman A , Adolph C, Vogel T, Unger A, Moeslin G. High-dose tamoxifen and sulindac as first-line treatment for desmoid tumors . Cancer 2004 ; 100 : 612 – 620 . Google Scholar Crossref Search ADS PubMed WorldCat 2 Church JM . Desmoid tumors in patients with familial adenomatous polyposis . Semin Colon Rectal Surg 1995 ; 6 : 29 – 32 . Google Scholar OpenURL Placeholder Text WorldCat Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
TI - A 10-year review of surgery for desmoid disease associated with familial adenomatous polyposis (Br J Surg 2006; 93; 1258–1264)
JF - British Journal of Surgery
DO - 10.1002/bjs.5773
DA - 2007-01-29
UR - https://www.deepdyve.com/lp/oxford-university-press/a-10-year-review-of-surgery-for-desmoid-disease-associated-with-C7xzDxP6Jh
SP - 251
EP - 251
VL - 94
IS - 2
DP - DeepDyve
ER -