TY - JOUR
AU - Howell, Alexandra L.
AB -  A major challenge for using native and modified T cell epitopes to induce or suppress immunity relates to achieving efficient uptake and processing by antigen-presenting cells (APC) in vivo. IgG Fc receptors, which are expressed constitutively by professional APC including monocytes and dendritic cells, have long been known to mediate antigen uptake in a manner leading to efficient T cell activation. We have previously demonstrated enhanced presentation of antigenic and antagonistic peptides by targeting them to the type I Fc receptor for IgG (FcγRI, CD64) on human monocytes. In the present report we review the literature suggesting that CD64-targeted antigens are likely to be effective in vivo, and present data demonstrating enhanced immunogenicity in CD64 transgenic mice of a fusion protein that combines the specificities of HIV gp120 and the humanized anti-CD64 monoclonal antibody H22. Overall, these studies suggest that targeting antigens to CD64 represents an effective approach to enhancing the effectiveness of vaccines in vivo.
TI - Increased potency of Fc-receptor-targeted antigens
JF - Cancer Immunology Immunotherapy
DO - 10.1007/s002620050418
DA - 1997-11-24
UR - https://www.deepdyve.com/lp/springer-journals/increased-potency-of-fc-receptor-targeted-antigens-C75VKGHHDs
SP - 146
EP - 148
VL - 45
IS - 4
DP - DeepDyve
ER -