TY - JOUR
AU - Alison A. Beharka, Mohsen Meydani, Dayong Wu, Lynette S. Leka, Ahou Meydani, Simin Nikbin Meydani
AB - Investigators have reported an increase, decrease, or no effect of age on interleukin-6 (IL-6) production. Differences in experimental conditions and the health status of subjects may explain these contradicting results. Because the subjects used in most of the previous studies were not carefully screened for health, we investigated the effect of age on IL-6 production in healthy young and elderly subjects. Twenty young (aged 20–30 years) and 26 elderly (>65 years) men completed the study. Each subject was screened for good health, undergoing physical examinations and laboratory tests. Circulating IL-6 levels were not significantly different between young and elderly subjects. A subgroup of subjects representing both young and elderly volunteers had high (>1000 pg/ml) circulating levels of IL-6. However, circulating IL-6 levels were low (<100 pg/ml) in the majority of subjects in both age groups. Peripheral blood mononuclear cells (PBMC) were cultured for IL-6 production in the presence or absence of phytohemagglutinin (PHA) or concanavalin (Con)A for 48 hours. Unstimulated secretion of IL-6 by PBMC cultured in autologous plasma (AP) or fetal bovine serum (FBS) was detectable in the majority of cultures. Age did not influence this spontaneous secretion of IL-6. PBMC stimulation with PHA or ConA significantly increased IL-6 production, but age did not affect the ability of PBMC to secrete IL-6 after stimulation when cultured in FBS. IL-6 production by PBMC cultured in AP and stimulated with PHA was not affected by age. However, when stimulated with ConA, PBMC from the elderly subjects produced less IL-6 than PBMC from the young subjects. Because IL-6 has been suggested to contribute to the age-related increase in prostaglandin (PG)E 2 and nitric oxide (NO) production, we investigated the effect of age on the production of IL-6 by murine peritoneal macrophages (Mϕ) as well as the effect of IL-6 on the production of other Mϕ inflammatory products. Similar to the findings in humans, mouse age did not influence the level of IL-6 produced by Mϕ. These data suggest that in healthy subjects, increased production of IL-6 is not a normal consequence of aging. Previously reported higher IL-6 levels in elderly subjects might reflect an underlying, undiagnosed disease state. PGE 2 and NO production were not affected by the addition of IL-6 to Mϕ from young mice or anti-IL-6 antibody to Mϕ from old mice. Thus, IL-6 does not appear to influence the Mϕ production of selected inflammatory molecules. The Gerontological Society of America « Previous | Next Article » Table of Contents This Article J Gerontol A Biol Sci Med Sci (2001) 56 (2): B81-B88. doi: 10.1093/gerona/56.2.B81 » Abstract Free Full Text (HTML) Free Full Text (PDF) Free Classifications Journal of Gerontology: Biological Sciences Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Beharka, A. A. Articles by Meydani, S. N. Search for related content PubMed PubMed citation Articles by Beharka, A. A. Articles by Meydani, M. Articles by Wu, D. Articles by Leka, L. S. Articles by Meydani, A. Articles by Meydani, S. N. 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TI - Interleukin-6 Production Does Not Increase With Age
JO - The Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences
DO - 10.1093/gerona/56.2.B81
DA - 2001-02-01
UR - https://www.deepdyve.com/lp/oxford-university-press/interleukin-6-production-does-not-increase-with-age-C5AxXyWM1n
SP - B81
VL - 56
IS - 2
DP - DeepDyve
ER -