TY - JOUR AU - da Silva Filho, Luiz Vicente Ribeiro Ferreira AB - Pediatric Pulmonology 51:1122–1130 (2016) Albuterol Via Metered-Dose Inhaler in Children: Lower Doses Are Effective, and Higher Doses Are Safe 1,2 1 Fabio Pereira Muchao, MD, MSc, Juliana Miguita e Souza, MD, 1 1 Helida Conceic S ao Cavalcante Torres, MD, Isabella Batista De Lalibera, MD, 2 1 1 Andrea Vieira de Souza, PhD, Joaquim Carlos Rodrigues, MD, PhD, Claudio Schvartsman, MD, PhD, 1,2,3 and Luiz Vicente Ribeiro Ferreira da Silva Filho, MD, PhD * Summary. Background: The ideal dosing of albuterol via metered-dose inhalers for acute childhood asthma is not well established. We hypothesized that greater doses of albuterol would result in less time in the hospital and lower admission rates. Methods: This was a randomized controlled double-blind multicenter study, conducted in emergency rooms (ER). We included patients with 2–17 years old with moderate to severe acute asthma (Pediatric Respiratory Assessment Measure, PRAM, score 5). Dosages administered during the first hour included: 6 (up to 25 kg) or 12 puffs (>25 kg) in the control group and 9 (up to 15 kg), 12 (>15–20 kg), 15 (>20–25 kg), or 18 puffs (>25 kg) in the study group. Several efficacy (changes in PRAM score, pulse oximetry, and FEV , length TI - Albuterol via metered‐dose inhaler in children: Lower doses are effective, and higher doses are safe JF - Pediatric Pulmonology DO - 10.1002/ppul.23469 DA - 2016-11-01 UR - https://www.deepdyve.com/lp/wiley/albuterol-via-metered-dose-inhaler-in-children-lower-doses-are-C27yyOrFPQ SP - 1122 EP - 1130 VL - 51 IS - 11 DP - DeepDyve ER -