TY - JOUR
AU1 - Cahill, David, J.
AU2 - Wardle, Peter, G.
AU3 - Maile, Laura, A.
AU4 - Harlow, Christopher, R.
AU5 - Hull, Michael, G.R.
AB - Abstract This study examines circulating and follicular hormone concentrations and fertilization of oocytes in cycles totally unperturbed by exogenous gonadotrophins in 10 women (25 cycles) with untreated minimal—mild endometriosis and nine women (23 cycles) with prolonged unexplained infertility compared with 16 women (50 cycles) with tubal damage as functional controls. Endometriosis was associated with a significantly longer follicular phase (median 15,12,13 days respectively) and reduced oestrogen secretion (median index area under the curve 3063, 3842, 3805 units respectively) compared with controls. Both endometriosis and unexplained infertility had significantly reduced serum luteinizing hormone (LH) surges [median peak serum (LH) 43, 39, 55 IU/1 respectively and median area under the curve 661, 687, 823 units respectively] and reduced LH concentrations in follicular fluid (median 19.6, 10.6, 9.2 IU/1 respectively). These findings suggest that infertility associated with minor endometriosis and of apparently unexplained aetiology share a common pathophysiology in impaired LH surge secretion. Whether that represents a primary pituitary disorder or is secondary to a defective ovarian signal is discussed. impaired LH secretion, minor endometriosis, natural cycle IVF, unexplained infertility This content is only available as a PDF. Author notes *Presented in part at the 25th British Congress of Obstetrics and Gynaecology, Dublin, Ireland, July 4—7, 1995 © Oxford University Press
TI - Pituitary—ovarian dysfunction as a cause for endometriosis-associated and unexplained infertility
JF - Human Reproduction
DO - 10.1093/oxfordjournals.humrep.a135876
DA - 1995-12-01
UR - https://www.deepdyve.com/lp/oxford-university-press/pituitary-ovarian-dysfunction-as-a-cause-for-endometriosis-associated-Bu7dCPMy6t
SP - 3142
EP - 3146
VL - 10
IS - 12
DP - DeepDyve
ER -