TY - JOUR AU - Wedel, Barbara J. AB - INTRODUCTIONInsects play a crucial role in maintaining a balance in the global ecosystem and within the food chain.1 However, several thousand insect species are known to damage agricultural crops by consuming plant tissues, extracting plant nutrients, or transmitting pathogenic viruses. The two major insect agricultural pest segments are chewing insects (lepidopterans and coleopterans) and piercing sucking insects (homopterans and thysanopterans). Over time, diverse chemical insecticides have emerged as important tools to protect crops from insect pests (Fig. 1). In the current global insecticide market, worth $18.4 billion,2 chewing insect control predominates. Out of a broad set of synthetic compounds, neonicotinoids, pyrethroids and diamides are the top three contributors to the global insecticide market.1FigureInsecticide solutions (based on the information cited in Sparks and Bryant2).However, with the increasing regulatory stringency, neonicotinoids with lower bee end points will face more regulatory challenges.3–5 Also, diamides (Chlorantraniliprole and Cyantraniliprole) are under tremendous pressure since they become generic in 2024 and resistance against key lepidopteran pests (e.g., Plutella xylostella) has emerged globally.6 In the current scenario, there is an urgent need to find new solutions to address the chewing insect segment. The voltage‐dependent sodium channel blockers indoxacarb and metaflumizone are key solutions for control of lepidopterans TI - Discovery of novel pyrazoline insecticides JF - Pest Management Science DO - 10.1002/ps.8547 DA - 2025-05-01 UR - https://www.deepdyve.com/lp/wiley/discovery-of-novel-pyrazoline-insecticides-BhCL3bxw3S SP - 2553 EP - 2565 VL - 81 IS - 5 DP - DeepDyve ER -