TY - JOUR
AU - Barker, Roger A.
AB - Background: There is currently little evidence regarding the selection ofpatients for clinical trials in Parkinson's Disease (PD), especially thoseinvolving experimental therapies delivered using invasive techniques. Objective:Understanding which patients are recruited will increase awareness of issuesregarding parity of access to clinical trials and have an impact on the widerapplicability of results, as well as provoking discussion regarding futureimprovements in the enrolment process. Methods: TRANSEURO is an open labelmulti-centre surgical transplant trial which seeks to investigate thefeasibility and efficacy of grafts of human foetal ventral mesencephalic tissuein patients with PD. The Cambridge based cohort of TRANSEURO participants (n =26) was compared with a population representative sample of patients with PDeligible for, but not enrolled in, TRANSEURO (n = 33). Measurements wereavailable in both populations for demographics, neuropsychological tests, testsof motor and non-motor function and quality of life. Results: Patients enrolledin TRANSEURO were younger and had significantly more years of education withhigher scores on the revised Addenbrooke's Cognitive Examination. Thisdifference was accounted for by memory, fluency and visuospatial subscores.There were significant differences in the Movement Disorder Society Unified PDRating Scale scores with better motor function but more motor complications inthe enrolled group. Those enrolled were also more likely to be under the care ofthe principal investigator of the study. Conclusions: In this trial ourpopulation was younger and more educated with higher cognitive scores and bettermotor function than eligible PD patients not enrolled. This raises interestingquestions about the parity of access to clinical trials of this nature amongstpatients with PD.
TI - Which Patients with Parkinson's Disease Participate in Clinical                    Trials? One Centre's Experiences with a New Cell Based Therapy Trial                    (TRANSEURO)
JF - Journal of Parkinson s Disease
DO - 10.3233/jpd-140432
DA - 0001-01-01
UR - https://www.deepdyve.com/lp/ios-press/which-patients-with-parkinson-s-disease-participate-in-clinical-trials-BcwcHaNypT
SP - 671
EP - 676
VL - 4
IS - 4
DP - DeepDyve
ER -