TY - JOUR
AU - LARKINS, R., G.
AB - Abstract Successful establishment of pregnancy is dependent on inhibition of clotting and suppression of the maternal immune response at the feto-maternal interface. Early human placental production of prostacyclin (PGI2) and prostaglandin E2 (PGE2) may be important in this process. To examine the possible role of these PGs, we studied PGE and 6-keto-PGF1α (stable metabolite of PGI2) synthesis in human placental (9–17 weeks gestation) organ cultures, and monolayer cultures of purified trophoblasts. PGE2 appeared to be the major prostanoid formed. Other arachidonic acid metabolites identified in placental organ culture were 6-keto-PGF1α, thromboxane B2, PGF2α, leukotriene B4, 5(S)-hydroxyeicosatetraenoic acid (5-HETE), 12-HETE, and 15-HETE. The synthesis of PGE and 6-keto-PGF1α altered with gestation and was maximal in the younger placentas. Arachidonic acid (33 μm) stimulated and indomethacin (28 μm) inhibited PG production. hCG, including physiological concentrations, stimulated PGE and 6-keto-PGF1α synthesis in placental organ cultures. This effect was most striking in the 9–12 week placentas, compared to 15–17 week placentas. A similar hCG-induced stimulation of PGE production occurred in monolayer cultures of trophoblasts. The addition of TSH, FSH, and LH indicated that this effect was specific for hCG. These data suggest that hCG may have a biological role in the regulation of PG synthesis in early human placenta. This content is only available as a PDF. Author notes * Postgraduate medical research scholar of the National Health and Medical Research Council of Australia at the time of these studies. Copyright © 1991 by The Endocrine Society
TI - Stimulation by Human Chorionic Gonadotropin of Prostaglandin Synthesis by Early Human Placental Tissue
JO - Journal of Clinical Endocrinology and Metabolism
DO - 10.1210/jcem-73-1-60
DA - 1991-07-01
UR - https://www.deepdyve.com/lp/oxford-university-press/stimulation-by-human-chorionic-gonadotropin-of-prostaglandin-synthesis-BP8vLAniHW
SP - 60
EP - 70
VL - 73
IS - 1
DP - DeepDyve
ER -