TY - JOUR
AU1 - Giordano, Piero C.
AB -  Because the diagnosis of beta thalassemia trait relies more and more on the automatic measurement of the HbA2 fraction with dedicated devices, Paleari et al. are rightfully concerned with the interlaboratory alignment of the different methods used to estimate this fraction. Precision is above all the aim of all laboratories and laboratory tests, and the use of a stable and universal HbA2 standard, as recommended by the authors, is essential. Paleari et al. send with their paper an important message to be taken into consideration by manufacturers and users. On the other hand, both manufacturers and users should also consider that, besides the quality and precision of the standard, there are other factors that may cause interdevice variability. The first factor is that the precision of the apparatus is dependent also on the amount of hemoglobin loaded. Although this parameter is kept within safe ranges by the constant loading volume, the variability and condition of the samples that inevitably have different MCH and RBC values and the degree of sedimentation will cause some variability in the amount of hemoglobin loaded on the column. The lower the amount of Hb loaded, the smaller will be the area of the 
TI - Editorial: Measurement of HbA2
JF - International Journal of Laboratory Hematology
DO - 10.1111/j.1751-553X.2012.01399.x
DA - 2012-08-01
UR - https://www.deepdyve.com/lp/wiley/editorial-measurement-of-hba2-BFRV8CDQIA
SP - 335
VL - 34
IS - 4
DP - DeepDyve
ER -