TY - JOUR
AU1 - Sanyal, Kasturi
AU2 - Debnath, Mita Chatterjee
AB - Protection of the thiolate function of dimercaptosuccinic acid (DMSA) and ethylenedi‐l‐cysteine diethyl ester (ECD) by S‐thiomethylation allowed automatic deprotection during technetium‐99m (99mTc) radiolabelling by direct reduction with stannous chloride dihydrate. Protection of the free thiolate group increased the stability of the ligands as well as deprotection during complexation, which resulted in the desired radiopharmaceuticals. The complexes obtained from the protected ligands were chromatographically (HPLC) and biologically compared with the corresponding 99mTc complexes of the unprotected ligands. The results suggest that the aforementioned method of protection by S‐thiomethylation could be utilized for the development of single‐vial DMSA and ECD kit. Copyright © 2012 John Wiley & Sons, Ltd.
TI - Synthesis of S ‐thiomethyl DMSA and S ‐thiomethyl ECD, radiolabelling with technetium‐99m and biological evaluation
JF - Journal of Labelled Compounds and Radiopharmaceuticals
DO - 10.1002/jlcr.2922
DA - 2012-06-15
UR - https://www.deepdyve.com/lp/wiley/synthesis-of-s-thiomethyl-dmsa-and-s-thiomethyl-ecd-radiolabelling-B8MMUAaVD7
SP - 258
EP - 263
VL - 55
IS - 7
DP - DeepDyve
ER -