TY - JOUR
AU - Arron, S.T.
AB - SummaryNonmelanoma skin cancer (NMSC) is the most common cancer in the U.S.A. The two most common NMSCs are basal cell carcinoma and squamous cell carcinoma. The associations of single‐nucleotide polymorphisms (SNPs) in pigmentation pathway genes with NMSC are not well characterized. There is a series of epidemiological studies that have tested these relationships, but there is no recent summary of these findings. To explain overarching trends, we undertook a systematic review of published studies. The summarized data support the concept that specific SNPs in the pigmentation pathway are of importance for the pathogenesis of NMSC. The SNPs with the most promising evidence include MC1R rs1805007(T) (Arg151Cys) and rs1805008(T) (Arg160Trp), and ASIP AH haplotype [rs4911414(T) and rs1015362(G)]. There are a few other SNPs found in TYR, OCA2 and SLC45A2 that may show additional correlation after future research. With additional research there is potential for the translation of future findings to the clinic in the form of SNP screenings, where patients at high risk for NMSC can be identified beyond their phenotype by genotypically screening for predisposing SNPs.
TI - Single‐nucleotide polymorphisms in pigment genes and nonmelanoma skin cancer predisposition: a systematic review
JO - British Journal of Dermatology
DO - 10.1111/bjd.13283
DA - 2014-10-01
UR - https://www.deepdyve.com/lp/oxford-university-press/single-nucleotide-polymorphisms-in-pigment-genes-and-nonmelanoma-skin-B6tjDRLg88
SP - 713
EP - 721
VL - 171
IS - 4
DP - DeepDyve
ER -