TY - JOUR
AU - Francesco Smeraglia, Angelo Del Buono, Nicola Maffulli
AB - Introduction In the last few years, the use of collagenase clostridium histolyticum for management of Dupuytren's contracture has increased. The procedure of enzymatic fasciectomy has become popular because it is non-invasive, safe and fast to perform. Sources of data A systematic search was performed on Medline (PubMed), Web of Science and Scopus databases using the combined keywords ‘Dupuytren collagenase’ and ‘Dupuytren clostridium histolyticum’. Forty-three studies were identified. The quality of the studies was assessed using the Coleman Methodological Score. Areas of agreement The use of collagenase clostridium histolyticum provides better outcomes in patients with mild-moderate joint contracture, with lower complications and side effects than open fasciectomy. Manipulation can be performed 2–7 days after the injection. The use of collagenase is cost-effective. Areas of controversy Most of the studies did not report patient-related outcomes. The role of dynamic splint has to be investigated with randomized clinical trials. Growing points The shorter recovery time and the low incidence of serious or major adverse effects are the main advantages of this new technology. Areas timely for developing research There is a need to perform studies with longer follow-up because the recurrence rate seems to increase with time. Further investigations are necessary to assess whether it is safe and effective to inject two or more cords at the same time. Key words Dupuytren collagenase non-operative clostridium histolyticum contracture © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com « Previous Table of Contents This Article Br Med Bull (2016) 118 (1): 149-158. doi: 10.1093/bmb/ldw020 First published online: May 5, 2016 » Abstract Free Full Text (HTML) Free Full Text (PDF) Free All Versions of this Article: ldw020v1 118/1/149 most recent Classifications Invited review Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Disclaimer Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Google Scholar Articles by Smeraglia, F. Articles by Maffulli, N. PubMed PubMed citation Articles by Smeraglia, F. Articles by Del Buono, A. Articles by Maffulli, N. 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TI - Collagenase clostridium histolyticum in Dupuytren's contracture: a systematic review
JO - British Medical Bulletin
DO - 10.1093/bmb/ldw020
DA - 2016-06-01
UR - https://www.deepdyve.com/lp/oxford-university-press/collagenase-clostridium-histolyticum-in-dupuytren-s-contracture-a-AzE6bqvgYD
SP - 149
VL - 118
IS - 1
DP - DeepDyve
ER -