TY - JOUR
AU - Kanegane, Hirokazu
AB - Journal of Clinical Immunology (2021) 41:1954–1956 https://doi.org/10.1007/s10875-021-01124-1 LE T TER TO   EDITOR Hematopoietic Cell Transplantation Ameliorates Autoinflammation in A20 Haploinsufficiency 1 2 3 3 2,4 5 Mayuka Shiraki  · Eleri Williams  · Norifumi Yokoyama  · Kunihiro Shinoda  · Zohreh Nademi  · Kana Matsumoto  · 6 6,7,8 6 9 2,5 2 Hiroshi Nihira  · Yoshitaka Honda  · Kazushi Izawa  · Ryuta Nishikomori  · Mary A. Slatter  · Andrew J. Cant  · 2,5 1,10 11 Andrew R. Gennery  · Hidenori Ohnishi  · Hirokazu Kanegane Received: 29 April 2021 / Accepted: 16 August 2021 / Published online: 24 August 2021 © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 To the Editor: Patient 1 was a British boy with type 1 diabetes mel- litus (T1DM) (with positive anti-islet antibodies), cyto- A20 haploinsufficiency (HA20) is caused by heterozygous penia, hepatitis, enteropathy, interstitial lung disease, and loss-of function variants in TNFAIP3, which has a critical anti-glutamic acid decarboxylase (GAD) antibodies at age function in the inhibition of key proinflammatory pathways, 10 years [2]. He was identified as having a heterozygous including inhibitor of nuclear factor kappa B (NF-κB) sign- c.1466_1467delTG variant in TNFAIP3 after HCT. The aling pathway and interferon regulatory factor pathway with pre-HCT clinical course was refractory to intensive immu- the post-translational modifications by 
TI - Hematopoietic Cell Transplantation Ameliorates Autoinflammation in A20 Haploinsufficiency
JF - Journal of Clinical Immunology
DO - 10.1007/s10875-021-01124-1
DA - 2021-11-01
UR - https://www.deepdyve.com/lp/springer-journals/hematopoietic-cell-transplantation-ameliorates-autoinflammation-in-a20-AvBcSKsaNR
SP - 1954
EP - 1956
VL - 41
IS - 8
DP - DeepDyve
ER -