TY - JOUR
AU1 - Rodrigues, Sofia Grenho
AU2 - Vieira, Daniela
AU3 - Bernardo, Francisco
AU4 - Coelho, Joana
AU5 - Ribeiro, Joana Afonso
AU6 - Palavra, Filipe
AU7 - Robalo, Conceição
AU8 - Levy, António
AU9 - Quintas, Sofia
AB - IntroductionPediatric cerebral sinus venous thrombosis (CSVT) is a rare entity. Risk factors differ from the adults, and treatment is not consensual. With this work, we aimed to characterize a pediatric cohort from two Portuguese tertiary centers.MethodsAll patients under 18 years old with confirmed CSVT admitted between 2006 and 2019 were retrospectively included. Demographics, clinical presentation, workup, and follow-up were evaluated.ResultsFifty-three patients were included, 29 were male (54.7%). Median age was 5 years (IQR 11.08, range 0–17 years old). Headache, seizures and impairment of consciousness were the most frequent manifestations. A risk factor was identified in 90.6% (n = 48), mostly infections (43.8%; n = 21). CNS complications were comprised of hemorrhage, venous infarction, hydrocephalus and edema. Treatment included anticoagulation in 36 patients (67.9%), and there were no recurrences on follow-up. Prognosis was favorable, with most patients presenting no or only slight disability comparing to same age and sex children, on the follow-up.DiscussionIn this cohort, impairment of consciousness was the most frequent clinical presentation and infections were the most frequent risk factors. The outcome was mainly favorable, with most patients presenting none or mild disability and without recurrences on follow-up. Studies are needed to define the criteria for anticoagulation and its recommended duration in children.
TI - Pediatric cerebral sinus venous thrombosis: clinical characterization of a Portuguese cohort
JF - Acta Neurologica Belgica
DO - 10.1007/s13760-021-01807-x
DA - 2022-10-01
UR - https://www.deepdyve.com/lp/springer-journals/pediatric-cerebral-sinus-venous-thrombosis-clinical-characterization-ArYzUTAEH8
SP - 1211
EP - 1218
VL - 122
IS - 5
DP - DeepDyve
ER -