TY - JOUR
AU1 - Abidin, Nur Fauziani Zainul
AU2 - Rahman, Fairuz Abdul
AU3 - Tuck Choon, Kok
AU4 - Tilakaratne, Wanninayake Mudiyanselage
AB - BackgroundEBV-associated smooth muscle tumors (EBV-SMTs) are rare and typically develop in individuals with a compromised immune system, particularly those who have acquired immunodeficiency syndrome (AIDS) or who have undergone organ transplants.MethodsWe document a case of EBV-SMT in an HIV-positive 25-year-old man. The lesion was incised and assessed histologically and a panel of immune markers were performed. EBV association was demonstrated by in situ hybridization for EBV-encoded RNA (EBER-ISH).ResultsMicroscopically, the tumor composed of mildly pleomorphic, ovoid to spindled cells with numerous slit-like vascular channels. The tumor cells exhibited diffuse and strong immunoreactivity for smooth muscle actin (SMA) and focal positivity for h-caldesmon. EBER-ISH of the tumor cells revealed strong positive nuclear signals.ConclusionThe histopathological features of EBV-SMT do not conform to either benign or malignant SMTs and it has a peculiar predilection to develop at sites unusual for leiomyoma or leiomyosarcoma. The key diagnostic features of EBV-SMT include history of immunosuppression, histologic evidence of primitive and mildly pleomorphic cells maintaining blunt nuclear features in most areas, and positivity for EBER-ISH.
TI - EBV-Associated Smooth Muscle Tumor in the Malar Area of an HIV-Positive Patient: A Case Report
JF - Head and Neck Pathology
DO - 10.1007/s12105-023-01560-y
DA - 2023-09-01
UR - https://www.deepdyve.com/lp/springer-journals/ebv-associated-smooth-muscle-tumor-in-the-malar-area-of-an-hiv-AXsfe5Ury0
SP - 821
EP - 825
VL - 17
IS - 3
DP - DeepDyve
ER -