TY - JOUR AU - Ewens, Warren J AB - Published by Oxford University Press on behalf of the International Epidemiological Association International Journal of Epidemiology 2008;37:447–451 doi:10.1093/ije/dyn049 The Author 2008; all rights reserved. Commentary: On Haldane’s ‘defense of beanbag genetics’ Warren J Ewens Accepted 23 January 2008 natural selection was severely limited because too Introduction rapid a rate would require an unbearable offspring It is now almost 45 years since Haldane’s ‘Defense requirement on selectively favoured individuals. This of beanbag genetics’ appeared, and the time is ripe argument, together with further calculations made for an evaluation of that defence, particularly in the 6 mainly by Kimura, became the initial impetus for light of developments over the last two decades. This Kimura’s controversial neutral theory of evolution. deliberately provocative review is divided into four This is not the place to go into the detailed parts: first, a discussion of why Haldane felt that mathematics of why I for one, and many others, a defence was necessary; second, a review of what his find the mathematical calculations supporting the defence actually was; third, suggestions as to what neutral theory to be misguided. It is sufficient to note his defence should have been; and fourth, a discus- for the purposes of TI - Commentary: On Haldane's ‘defense of beanbag genetics’ JF - International Journal of Epidemiology DO - 10.1093/ije/dyn049 DA - 2008-06-01 UR - https://www.deepdyve.com/lp/oxford-university-press/commentary-on-haldane-s-defense-of-beanbag-genetics-ARbYiB6lLR SP - 447 EP - 451 VL - 37 IS - 3 DP - DeepDyve ER -