TY - JOUR
AU1 - Gawlitza, Matthias
AU2 - Fiedler, Eckhard
AU3 - Schob, Stefan
AU4 - Hoffmann, Karl-Titus
AU5 - Surov, Alexey
AB - Purpose: The aim of this study was to investigate to which degree the peritumoral brain edema in patients with meningiomas depends on aquaporin-4 (AQP4) expression, tumor grade, tumor volume, Ki-67 expression, and cell count. Procedures: Thirty-three patients (25 women, 8 men; mean age 56.6 ± 16.0 years) with an intracranial meningioma underwent a standardized magnetic resonance (MR) examination prior to surgical resection. Edema indices (EIs) and tumor volumes were measured on the MR images. Tumor grade was classified according to the World Health Organization, and the proliferation index was estimated on Ki-67 antigen-stained specimens. Tumor cell count was evaluated. Eighteen specimens were stained for AQP4 expressioon. Results: Significant intergroup differences between AQP4 expression grades and EIs were observed (P = 0.03), and a positive correlation was detected between EIs and AQP4 expression grades (r = 0.54; P G 0.05). A ROC analysis with EI as a test variable revealed an AUC of 0.77 (95 % CI 0.55–0.99) for the prediction of a moderate-to-strong AQP4 expression. An EI ≥1.5 predicted a moderate-to-high AQP4 expression with a sensitivity of 77 % and a specificity of 60 %. EI values of 2.2 and 3.5 reached sensitivity/specificity values of 69/80 % and 54/100 
TI - Peritumoral Brain Edema in Meningiomas Depends on Aquaporin-4 Expression and Not on Tumor Grade, Tumor Volume, Cell Count, or Ki-67 Labeling Index
JF - Molecular Imaging and Biology
DO - 10.1007/s11307-016-1000-7
DA - 2016-08-23
UR - https://www.deepdyve.com/lp/springer-journals/peritumoral-brain-edema-in-meningiomas-depends-on-aquaporin-4-AA96x4a1hF
SP - 298
EP - 304
VL - 19
IS - 2
DP - DeepDyve
ER -