TY - JOUR
AU1 - Lee, Jee Young
AU2 - Park, Jung Tak
AU3 - Joo, Young Su
AU4 - Lee, Changhyun
AU5 - Yun, Hae-Ryong
AU6 - Chang, Tae Ik
AU7 - Kim, Yeong-Hoon
AU8 - Chung, WooKyung
AU9 - Yoo, Tae-Hyun
AU1 - Kang, Shin-Wook
AU1 - Park, Sue K
AU1 - Chae, Dong Wan
AU1 - Oh, Kook-Hwan
AU1 - Han, Seung Hyeok
AB - BackgroundOptimal blood pressure (BP) control is a major therapeutic strategy to reduce adverse cardiovascular events (CVEs) and mortality in patients with chronic kidney disease (CKD). We studied the association of BP with adverse cardiovascular outcome and all-cause death in patients with CKD.MethodsAmong 2238 participants from the KoreaN cohort study for Outcome in patients With CKD (KNOW-CKD), 2226 patients with baseline BP measurements were enrolled. The main predictor was systolic BP (SBP) categorized by five levels: <110, 110–119, 120–129, 130–139 and ≥140 mmHg. The primary endpoint was a composite outcome of all-cause death or incident CVEs. We primarily used marginal structural models (MSMs) using averaged and the most recent time-updated SBPs.ResultsDuring the follow-up of 10 233.79 person-years (median 4.60 years), the primary composite outcome occurred in 240 (10.8%) participants, with a corresponding incidence rate of 23.5 [95% confidence interval (CI) 20.7–26.6]/1000 patient-years. MSMs with averaged SBP showed a U-shaped relationship with the primary outcome. Compared with time-updated SBP of 110–119 mmHg, hazard ratios (95% CI) for <110, 120–129, 130–139 and ≥140 mmHg were 2.47 (1.48–4.11), 1.29 (0.80–2.08), 2.15 (1.26–3.69) and 2.19 (1.19–4.01), respectively. MSMs with the most recent SBP also showed similar findings.ConclusionsIn Korean patients with CKD, there was a U-shaped association of SBP with the risk of adverse clinical outcomes. Our findings highlight the importance of BP control and suggest a potential hazard of SBP <110 mmHg.
TI - Association of blood pressure with cardiovascular outcome and mortality: results from the KNOW-CKD study
JF - Nephrology Dialysis Transplantation
DO - 10.1093/ndt/gfab257
DA - 2021-09-02
UR - https://www.deepdyve.com/lp/oxford-university-press/association-of-blood-pressure-with-cardiovascular-outcome-and-9ptbjh1kgb
SP - 1722
EP - 1730
VL - 37
IS - 9
DP - DeepDyve
ER -