TY - JOUR AU - AB - Research Article Vol. 30, No. 17 / 15 Aug 2022 / Optics Express 30246 Integrated optical device for Structured Illumination Microscopy 1 1,2 2 MATTEO CALVARESE, PETRA PAIÈ, ALESSIA CANDEO, 2 1 GIANMARIA CALISESI, FRANCESCO CECCARELLI, GIANLUCA 1,2 1 3 VALENTINI, ROBERTO OSELLAME, HAI GONG, MARK 3 1 1,2,* NEIL, FRANCESCA BRAGHERI, AND ANDREA BASSI Istituto di Fotonica e Nanotecnologie (IFN), Consiglio Nazionale delle Ricerche (CNR), Piazza Leonardo da Vinci 32, 20133 Milan, Italy Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milan, Italy Department of Physics, Imperial College London, South Kensington Campus London SW7 2AZ, UK andrea1.bassi@polimi.it Abstract: Structured Illumination Microscopy (SIM) is a key technology for high resolution and super-resolution imaging of biological cells and molecules. The spread of portable and easy-to-align SIM systems requires the development of novel methods to generate a light pattern and to shift it across the field of view of the microscope. Here we show a miniaturized chip that incorporates optical waveguides, splitters, and phase shifters, to generate a 2D structured illumination pattern suitable for SIM microscopy. The chip creates three point-sources, coherent and controlled in phase, without the need for further alignment. Placed in the pupil of TI - Integrated optical device for Structured Illumination Microscopy DO - 10.1101/2022.04.22.489094 DA - 2022-04-22 UR - https://www.deepdyve.com/lp/unpaywall/integrated-optical-device-for-structured-illumination-microscopy-9mjfLbiRoD DP - DeepDyve ER -