TY - JOUR
AU - Franca, M. C.
AB - Background and purpose Non‐motor manifestations are frequently overlooked in degenerative disorders and little is known about their frequency and clinical relevance in SPG4 hereditary spastic paraplegia (SPG4‐HSP). Methods Thirty patients with SPG4‐HSP and 30 healthy controls answered the Modified Fatigue Impact Scale, Epworth Sleepiness Scale, Brief Pain Inventory and Beck Depression Inventory. Student's t test was used to compare groups and linear regression was used to assess correlations. Results Patients had higher fatigue scores than controls (31.0 ± 16.5 vs. 14.5 ± 16.0, P = 0.002) as well as pain (3.4 ± 2.7 vs. 1.0 ± 1.6, P = 0.001) and depression (12.7 ± 8.9 vs. 4.4 ± 3.8, P < 0.001, respectively). Fatigue was associated with depression and possibly with disease severity (P = 0.008 and 0.07, respectively). Conclusions Fatigue, pain and depression are frequent and often severe manifestations in patients with SPG4‐HSP.
TI - Non‐motor symptoms in patients with hereditary spastic paraplegia caused by SPG4 mutations
JO - European Journal of Neurology
DO - 10.1111/ene.12839
DA - 2016-02-01
UR - https://www.deepdyve.com/lp/wiley/non-motor-symptoms-in-patients-with-hereditary-spastic-paraplegia-9K93ov8BoB
SP - 408
EP - 411
VL - 23
IS - 2
DP - DeepDyve
ER -