TY - JOUR AU - PITT-RIVERS, ROSALIND AB - STUDY OF THYROID METABOLISM WITH I J. Gross & Rosalind Pitt-Rivers precipitated with the plasma proteins; it was not dialyzable and it was extractable with butanol, without preliminary hydrolysis of the proteins. The advent of radioiodine allowed a more exact identification of the plasma hormone; this was first carried out by Taurog & Chaikoff (1948), who applied the methods of Trevorrow to plasma from animals previously EXPERIMENTAL STUDY OF injected with radioiodine. They also showed that, after the THYROID METABOLISM WITH addition of crystalline thyroxine to the plasma of animals 1I1 injected with I, the radioactivity followed the carrier- RADIOACTIVE IODINE substance, which could be recrystaltized to a constant specific activity. This was subsequently confirmed by Leblond & Gross (1949). The application of paper partition chromato- J. GROSS* M.D. CM. Ph.D. graphy to the analysis of plasma iodine of animals (Laidlaw, ROSALIND PITT-RIVERS M.Sc. Ph.D. 1949; Taurog, Chaikoff & Tong, 1950; Gross et al. 1950) indicated that the greatest portion of the plasma iodine moved National Institute for Medical Research to the same position on the chromatograms as thyroxine Mill Hill, London (Plate HI, fig. G) ; the presence of thyroxine in human plasma has recently been detected (Rail, TI - EXPERIMENTAL STUDY OF THYROID METABOLISM WITH RADIOACTIVE IODINE JF - British Medical Bulletin DO - 10.1093/oxfordjournals.bmb.a074096 DA - 1951-01-01 UR - https://www.deepdyve.com/lp/oxford-university-press/experimental-study-of-thyroid-metabolism-with-radioactive-iodine-9FpUHhV6r3 SP - 136 EP - 140 VL - 8 IS - 2-3 DP - DeepDyve ER -