TY - JOUR
AU1 - Upadhyay, Seema
AU2 - Khan, Iliyas
AU3 - Gothwal, Avinash
AU4 - Pachouri, Praveen
AU5 - Bhaskar, N.
AU6 - Gupta, Umesh
AU7 - Chauhan, Devendra
AU8 - Gupta, Umesh
AB - Pharm Res (2017) 34:1944–1955 DOI 10.1007/s11095-017-2206-3 RESEARCH PAPER Conjugated and Entrapped HPMA-PLA Nano-Polymeric Micelles Based Dual Delivery of First Line Anti TB Drugs: Improved and Safe Drug Delivery against Sensitive and Resistant Mycobacterium Tuberculosis 1 1 1 2 2 Seema Upadhyay & Iliyas Khan & Avinash Gothwal & Praveen K. Pachouri & N. Bhaskar & 2 2 1 Umesh D. Gupta & Devendra S. Chauhan & Umesh Gupta Received: 29 April 2017 /Accepted: 8 June 2017 /Published online: 6 July 2017 Springer Science+Business Media, LLC 2017 ABSTRACT respectively. MABA assay (cytotoxicity) based MIC values of Purpose First line antiTB drugs have several physical and PMRI formulation was observed as ≥0.0625 and ≥0.50 μg/ toxic manifestations which limit their applications. RIF is a mL (for sensitive and resistant strain). The microscopic analy- hydrophobic drug and has low water solubility and INH is sis further confirmed that the delivery approach was effective hepatotoxic. The main objective of the study was to synthe- than pure drugs. size, characterize HPMA-PLA co-polymeric micelles for the Conclusions RIF loaded and INH conjugated HPMA- effective dual delivery of INH and RIF. PLA polymeric micelles (PMRI) were more effective Methods HPMA-PLA co-polymer and HPMA-PLA-INH against sensitive and 
TI - Conjugated and Entrapped HPMA-PLA Nano-Polymeric Micelles Based Dual Delivery of First Line Anti TB Drugs: Improved and Safe Drug Delivery against Sensitive and Resistant Mycobacterium Tuberculosis
JF - Pharmaceutical Research
DO - 10.1007/s11095-017-2206-3
DA - 2017-07-06
UR - https://www.deepdyve.com/lp/springer-journals/conjugated-and-entrapped-hpma-pla-nano-polymeric-micelles-based-dual-9EUIALZqIv
SP - 1944
EP - 1955
VL - 34
IS - 9
DP - DeepDyve
ER -