TY - JOUR
AU - Drewes, Aø. Mohr
AB -  Previous methods for visceral thermal stimulation have lacked control of the temperature rate and visual inspection of the organ. The aim of the present study was to develop a new method for linear control of heat stimulation in the human esophagus combined with endoscopy and to assess the reproducibility of this method. A probe with a small endoscope inside permitting heat and chemical stimulation of the esophagus was constructed. In 12 healthy subjects three different temperature ramps were applied in the distal esophagus by recirculation of heated water in a bag. Endoscopy of the esophageal mucosa was done prior to experimental stimulation. The temperature, the time of stimulation and the area under the temperature curve (AUC) was measured at the pain detection threshold (PDT). Thermal stimulation was repeated after perfusion of the esophagus with acid. The method was tested on two subsequent days to assess reproducibility. All subjects had a normal endoscopic examination. Between‐days reproducibility was good for the three temperature ramps [intra‐class correlations (ICC) >0.6]. Following acid perfusion subjects tolerated less heat stimulation and a decrease in AUC (P = 0.0003) as well as in time to PDT (P = 0.005) and temperature at PDT (P = 
TI - 292 A NOVEL METHOD FOR THERMAL AND CHEMICAL STIMULATION OF THE HUMAN OESOPHAGUS
JF - European Journal of Pain
DO - 10.1016/S1090-3801(09)60295-0
DA - 2009-09-01
UR - https://www.deepdyve.com/lp/wiley/292-a-novel-method-for-thermal-and-chemical-stimulation-of-the-human-97ABeUFiXs
SP - S91
EP - S91
VL - 13
IS - S1
DP - DeepDyve
ER -