TY - JOUR
AU - Head, Richard J.
AB - Aortic ring preparations from spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats were treated with Nω-nitro-L-arginine (NOLA, 10–4M). This produced a sustained contraction in preparations from SHR but not WKY rats. A similar contraction in aortic ring preparations from the SHR was produced with methylene blue (10–5M)and NG-monomethyl-L-arginine (10–5M). The NOLA-induced contraction was reversed with indomethacin (8 × 10–6M), ridogrel (10–5M)and SQ 29548 (10–6M)thus confirming the involvement of thromboxane A2/prostaglandin H2 processes. Subsequent experiments demonstrated that the thromboxane-like contraction was not dependent upon the presence of endothelial cells and occurred in preparations from young, prehypertensive (5 week) and older (17 week) SHRs. The thromboxane-like contraction was markedly suppressed with chronic captopril treatment and reinstated 4 weeks after withdrawal from captopril. The addition of saralasin (10–6M) or captopril (10–6M) to aortic ring preparations did not suppress the thromboxane-like contractions. The foregoing findings support the presence of a nonendothelial cell thromboxane-like constrictor agent in the aorta of the SHR that is revealed after impairment of nitric oxide production. The activity of the thromboxane-like constrictor process is not tightly linked to prevailing blood pressure, but is reduced with chronic in vivo inhibition of the angiotensin-converting enzyme.
TI - Identification of a Nonendothelial Cell Thromboxane-Like Constrictor Response and Its Interaction with the Renin-Angiotensin System in the Aorta of Spontaneously Hypertensive Rats
JO - Journal of Vascular Research
DO - 10.1159/000159031
DA - 1994-01-01
UR - https://www.deepdyve.com/lp/karger/identification-of-a-nonendothelial-cell-thromboxane-like-constrictor-90Cvg8NCW8
SP - 52
EP - 60
VL - 31
IS - 1
DP - DeepDyve
ER -