TY - JOUR
AU - Liao, Yonghong
AB - Abstract
Background
Inhalation-based combination therapy has gained increasing attention for local treatments. However, a key challenge remains in ensuring the sustained pulmonary release of multiple active ingredients, particularly in traditional Chinese medicine (TCM) formulations.
Objective
This study investigates a novel PulmoSphere-based inhalable carrier designed for the sustained pulmonary release of multiple active ingredients, using Shuang-Huang-Lian as a model TCM formulation containing three chemical markers.
Materials and methods
The carrier was developed using PulmoSphere technology, incorporating phospholipid complexes of the chemical markers and hyaluronic acid (HA) into spray-dried microparticles. The aerodynamic properties, release characteristics, pulmonary distribution, and anti-inflammatory efficacy of different formulations were evaluated in vitro and in mice.
Results
The microparticles retained the excellent aerodynamic properties of conventional PulmoSphere particles, with a mass median aerodynamic diameter of approximately 3.1 μm and a fine particle fraction of approximately 55%. Compared to free Shuang-Huang-Lian or phospholipid complex-loaded PulmoSphere particles, the HA-containing particles prolonged the retention of chemical markers in the lung epithelial lining fluid, demonstrating sustained release in vivo. Additionally, the HA-containing formulation enhanced the exposure of the three chemical markers to immune cells and lung tissues, leading to improved and prolonged anti-inflammatory effects, even at decreased doses.
Conclusion
This novel inhalable particle system represents a promising approach for sustained pulmonary co-delivery of multiple active ingredients, offering enhanced and extended local therapeutic efficacy.

TI - Hyaluronic acid microparticles loaded with Shuang-Huang-Lian phospholipid complex for sustained pulmonary delivery: An in vitro and in vivo evaluation
JF - Science of Traditional Chinese Medicine
DO - 10.1097/st9.0000000000000068
DA - 2025-06-28
UR - https://www.deepdyve.com/lp/wolters-kluwer-health/hyaluronic-acid-microparticles-loaded-with-shuang-huang-lian-8r9in249r0
SP - 158
EP - 167
VL - 3
IS - 2
DP - DeepDyve
ER -