TY - JOUR
AU1 - Slomski, Anita
AB - News & Analysis Clinical Trials Update Repurposed Drugs Failed to Prevent a height-adjustable standing desk, or a con- Severe COVID-19 trol group that worked as usual. The inter- Atrialthatevaluated3existinggenericmedi- vention enlisted fellow employees to cham- cations—metformin, ivermectin, and fluvox- pion the importance of reducing sitting to amine—for early outpatient treatment of prevent adverse health effects and to serve SARS-CoV-2 infection among adults with as role models for sitting less than 50% of FPO overweight and obesity did not prevent pro- the day and moving every 30 minutes both gression to severe COVID-19. at work and at home. Workplaces were also The study randomly assigned 1431 par- changed to encourage employees to move ticipants to 1 of 6 trial groups: metformin more, such as relocating printers farther plus fluvoxamine; metformin plus ivermec- away. Participants’ sitting time was mea- tin; metformin plus placebo; placebo plus sured with an accelerometer. fluvoxamine; placebo plus ivermectin; and At 1 year, both intervention groups sat placebo plus placebo. Patients were en- less per day than the control group, but rolled in the study within 3 days of a con- the addition of a standing desk was 3 firmed infection and in fewer than 7 days 
TI - Repurposed Drugs Failed to Prevent Severe COVID-19
JF - JAMA
DO - 10.1001/jama.2022.14723
DA - 2022-09-27
UR - https://www.deepdyve.com/lp/american-medical-association/repurposed-drugs-failed-to-prevent-severe-covid-19-8fBf0OFNi5
SP - 1171
EP - 1171
VL - 328
IS - 12
DP - DeepDyve
ER -