TY - JOUR
AU - Rubin, Lorry G.
AB - Clonally related strains of Haemophilus influenzae biogroup aegyptius have recently been associated with Brazilian purpuric fever (BPF). Antibodies to a 145-kDa minor outer membrane protein (PI45) are bactericidal and protect against experimental bacteremia. To determine if P145 is conserved among case-clone strains, case-clone strains were screened for P145 expression. Assays of a large number of colonies of each strain using colony immunoblot revealed colonies reactive with anti-Pl45 sera in all 17 case-clone strains. P145 was expressed at a low frequency (0.08%-2.2% of colonies) in 14 strains and at a high fl1C1f1uency (> 98%) in 3 strains. Expression of P145 by reactive colonies was confirmed by SDS-PAGE. Also, anti-PI45nonreactive variant colonies of P 145-expressing strains were detected in 0.4%-1.5% of colonies. These findings indicate P 145 is conserved among BPF case-clone strains and is subject to phase variable expression.
TI - Phase-Variable Expression Of The 145-Kda Surface Protein Of Brazilian Purpuric Fever Case-Clone Strains Of Haemophilus Influenzae Biogroup Aegyptius
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/171.3.713
DA - 1995-03-01
UR - https://www.deepdyve.com/lp/oxford-university-press/phase-variable-expression-of-the-145-kda-surface-protein-of-brazilian-8Y13hI7YeQ
SP - 713
EP - 717
VL - 171
IS - 3
DP - DeepDyve
ER -