TY - JOUR
AU - Fondu, P., G.
AB - Abstract Iron overload increases the risk of bacterial infection in dialysis patients, partly by impairing functions of the polymorphonuclear granulocytes (PMNs). PMN defence was studied sequentially in haemodialysis patients with transfusional haemosiderosis, treated for 6 ±1.5 months (w = 8) to 13 ±1.7 months (n = 4) with recombinant human erythropoietin (rHuEpo). Over this period, signs of iron overload (increased serum ferritin and serum iron) improved, and stainable iron disappeared in PMNs. Simultaneously, phagocytosis of Yersinia enterocolitica by PMNs improved. The decrease in serum ferritin was significantly related to the improved phagocytosis. Killing of Y. enterocolitica by PMNs also improved. It is anticipated that rHuEpo therapy in ironoverloaded dialysis patients could decrease the incidence of bacterial infection by improving PMN functions in these patients Dialysis, Erythropoietin, Granulocyte function, Iron overload This content is only available as a PDF. © 1990 European Dialysis and Transplant Association-European Renal Association
TI - Recombinant Erythropoietin Reverses Polymorphonuclear Granulocyte Dysfunction in Iron-Overloaded Dialysis Patients
JO - Nephrology Dialysis Transplantation
DO - 10.1093/ndt/5.7.504
DA - 1990-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/recombinant-erythropoietin-reverses-polymorphonuclear-granulocyte-8UeGRkBVpf
SP - 504
EP - 507
VL - 5
IS - 7
DP - DeepDyve
ER -