TY - JOUR
AU - Goldman, David
AB - SEMINAL ARTICLES low, even immediately after alcohol consumption when acetaldehyde is being generated rapidly in the liver. Multiple aldehyde dehydrogenase enzymes exist and their structures are determined by different genes; however, this commentary examines o n l y t h e e n z y m e ( d e s i g n a t e d a s ALDH2) that is imported into the mitochondrion, the cell’s energy­ producing structure. The seminal ar­ t i c l e b y H a r a d a a n d c o l l e a g u e s , which actually is a detailed letter to the editor of the journal Lancet, first related the discovery of the effect of a genetic variant of this enzyme, which occurs very abundantly in Oriental populations (East Asians). ALDH2 is key in the metabolism of acetaldehyde produced after alco­ hol consumption. In 1948 Hald and J a c o b s e n i n t r o d u c e d d i s u l f i r a m (Antabuse ), an inhibitor of alde­ hyde dehydrogenase, for the clinical treatment of alcoholics. Disulfiram­ treated 
TI - Aldehyde Dehydrogenase Deficiency as Cause of Facial Flushing Reaction to Alcohol in Japanese
JO - Alcohol Health and Research World
DA - 0167-03-01
UR - https://www.deepdyve.com/lp/pubmed-central/aldehyde-dehydrogenase-deficiency-as-cause-of-facial-flushing-reaction-8I3Gb4HkPC
SP - 48
EP - 49
VL - 19
IS - 1
DP - DeepDyve
ER -