TY - JOUR
AU - Henner, David
AB - In contrast to disseminated extraneural germinoma, systemic chemotherapy in disseminated central nervous system germinoma often results in only transient responses. After surgery, cytoreduction was accomplished with systemic multiagent platinum-based chemotherapy in 4 consecutive patients known to have a poor prognosis, due to central nervous system germinoma at more than one anatomic site. When tumor enhancement resolved (i.e., blood-brain barrier integrity was restored), intensive consolidation therapy with carboplatin and etoposide was given in association with mannitol-induced osmotic blood-brain barrier disruption. Complete responses occurred in all 4 patients and currently 3 are tumor-free without radiotherapy 24–40 months from diagnosis, suggesting the importance of increased drug delivery for an extended period.
TI - Therapeutic Dilemma of Disseminated CNS Germoma and the Potential of Increased Platinum-Based Chemotherapy Delivery with Osmotic Blood-Brain Barrier Disruption
JF - Pediatric Neurosurgery
DO - 10.1159/000120809
DA - 1994-01-01
UR - https://www.deepdyve.com/lp/karger/therapeutic-dilemma-of-disseminated-cns-germoma-and-the-potential-of-8HKHIZolWX
SP - 16
EP - 22
VL - 21
IS - 1
DP - DeepDyve
ER -