TY - JOUR
AU - Zhu, Changfu
AB - We generated transgenic rice plants overexpressing Arabidopsis thaliana ρ-hydroxyphenylpyruvate dioxygenase (HPPD), which catalyzes the first committed step in vitamin E biosynthesis. Transgenic grains accumulated marginally higher levels of total tocochromanols than controls, reflecting a small increase in absolute tocotrienol synthesis (but no change in the relative abundance of the α and γ isoforms). In contrast, there was no change in the absolute tocopherol level, but a significant shift from the γ to the α isoform. These data confirm HPPD is not rate limiting, and that increasing flux through the early pathway reveals downstream bottlenecks that act as metabolic tipping points.
TI - Transgenic rice grains expressing a heterologous ρ-hydroxyphenylpyruvate dioxygenase shift tocopherol synthesis from the γ to the α isoform without increasing absolute tocopherol levels
JF - Transgenic Research
DO - 10.1007/s11248-012-9601-7
DA - 2012-02-24
UR - https://www.deepdyve.com/lp/springer-journals/transgenic-rice-grains-expressing-a-heterologous-hydroxyphenylpyruvate-8GXuh8z8CS
SP - 1093
EP - 1097
VL - 21
IS - 5
DP - DeepDyve
ER -