TY - JOUR
AU1 - Aripov, U.
AU2 - Sakhibov, A.
AU3 - Kasymov, B.
AU4 - Ziyaev, Kh.
AU5 - Biktimirov, L.
AU6 - Baram, N.
AU7 - Ismailov, A.
AB - CUMULATIVE PROPERTIES AND DISTRIBUTION OF A NEW IMMUNOSUPPRESSIVE COMPOUND U. A. Aripov, A. D. Sakhibov, B. Z. Kasymov, Kh. L. Ziyaev, L. Biktimirov, N. I. Baram, and A. I. Ismailov UDC 615.276.2.033.36 In connection with the growing requirements of clinical transplantology, the search for new drugs withimmunosuppressive properties is receiving considerable attention. The disodium salt of l,l',6,6'-tetrahydroxy-3,3'-dimethyl,5,5'.diisopropyl-7,7',dioxo-2,2'-di- naphthalene-8,8'-dimethyliminoethanesulfonic acid (I), synthesized at the Institute of Bioorganic Chemistry of the Academy of Sciences of the Uzbek SSR, has been proposed as a new immunosuppressor; its immunosuppressive properties have been studied at Tashkent Medical Institute. In the study of the pharmacokinetics of [~C]-I, the preparation was found to be charac- terized by the following: a nonuniformity of the distribution among organs with maximum accumulation in the liver; prolonged stay of radioactive product in the immunocompetent or- gans, i.e., spleen and thymus; substantial residual radioactivity in many organs after a single intraperitoneal injection; slow elimination of the drug and/or its radioactive metab- olites from the mouse organism (approximately 86% of the radioactivity introduced is elimi- nated, chiefly with the feces, within 7 days), These peculiarities of the distribution of [*~C]-I required a supplementaryinvestigation of the cumulative properties of the drug. For this 
TI - Cumulative properties and distribution of a new immunosuppressive compound
JF - Pharmaceutical Chemistry Journal
DO - 10.1007/BF00764682
DA - 2004-11-23
UR - https://www.deepdyve.com/lp/springer-journals/cumulative-properties-and-distribution-of-a-new-immunosuppressive-87fAF63ff3
SP - 528
EP - 531
VL - 17
IS - 8
DP - DeepDyve
ER -