TY - JOUR
AU1 - Joe, Carina C. D.
AU2 - Jiang, Jinlin
AU3 - Linke, Thomas
AU4 - Li, Yuanyuan
AU5 - Fedosyuk, Sofiya
AU6 - Gupta, Gaurav
AU7 - Berg, Adam
AU8 - Segireddy, Rameswara R.
AU9 - Mainwaring, David
AU1 - Joshi, Amar
AU1 - Cashen, Paul
AU1 - Rees, Byron
AU1 - Chopra, Nitin
AU1 - Nestola, Piergiuseppe
AU1 - Humphreys, Jonathan
AU1 - Davies, Sarah
AU1 - Smith, Nick
AU1 - Bruce, Scott
AU1 - Verbart, Dennis
AU2 - Bormans, Daan
AU2 - Knevelman, Carol
AU2 - Woodyer, Mark
AU2 - Davies, Lee
AU2 - Cooper, Lisa
AU2 - Kapanidou, Maria
AU2 - Bleckwenn, Nicole
AU2 - Pappas, Daniel
AU2 - Lambe, Teresa
AU2 - Smith, Daniel C.
AU3 - Green, Catherine M.
AU3 - Venkat, Raghavan
AU3 - Ritchie, Adam J.
AU3 - Gilbert, Sarah C.
AU3 - Turner, Richard
AU3 - Douglas, Alexander D.
AB - Manufacturing has been the key factor limiting rollout of vaccination during the COVID‐19 pandemic, requiring rapid development and large‐scale implementation of novel manufacturing technologies. ChAdOx1 nCoV‐19 (AZD1222, Vaxzevria) is an efficacious vaccine against SARS‐CoV‐2, based upon an adenovirus vector. We describe the development of a process for the production of this vaccine and others based upon the same platform, including novel features to facilitate very large‐scale production. We discuss the process economics and the “distributed manufacturing” approach we have taken to provide the vaccine at globally‐relevant scale and with international security of supply. Together, these approaches have enabled the largest viral vector manufacturing campaign to date, providing a substantial proportion of global COVID‐19 vaccine supply at low cost.
TI - Manufacturing a chimpanzee adenovirus‐vectored SARS‐CoV‐2 vaccine to meet global needs
JF - Biotechnology and Bioengineering
DO - 10.1002/bit.27945
DA - 2022-01-01
UR - https://www.deepdyve.com/lp/wiley/manufacturing-a-chimpanzee-adenovirus-vectored-sars-cov-2-vaccine-to-81aoJ3Uvl0
SP - 48
EP - 58
VL - 119
IS - 1
DP - DeepDyve
ER -