TY - JOUR
AU - Stocker, R.
AB - 
Objectives: Barbiturate coma is employed in brain-injured patients whenever increases in intracranial pressure remain unresponsive to less aggressive therapeutic regimens. Barbiturate-mediated neuroprotection, however, is weakened by an increased infection rate related to barbiturate-induced immunosuppression. Co-administration of barbiturates with antibiotics known to induce bone marrow suppression could, in turn, potentiate barbiturate-mediated immunosuppression. Adverse drug reactions and interactions of thiopental with antibiotics in terms of leukopenia, infection rate, and bone marrow suppression were investigated.
TI - Barbiturate coma may promote reversible bone marrow suppression in patients with severe isolated traumatic brain injury
JF - European Journal of Clinical Pharmacology
DO - 10.1007/s002280050508
DA - 1998-10-14
UR - https://www.deepdyve.com/lp/springer-journals/barbiturate-coma-may-promote-reversible-bone-marrow-suppression-in-7l4aBdUOip
SP - 529
EP - 534
VL - 54
IS - 7
DP - DeepDyve
ER -