TY - JOUR
AU1 - Nemet, Dan
AU2 - Hong, Suzi
AU3 - Mills, Paul J.
AU4 - Ziegler, Michael G.
AU5 - Hill, Maryann
AU6 - Cooper, Dan M.
AB - Abstract We hypothesized that brief exercise of a small muscle group would lead to local rather than systemic alterations in cytokines, peripheral blood mononuclear cells, and mediators of angiogenesis. Fifteen men and eight women (age range 22–36 yr old) performed 10 min of unilateral wrist flexion exercise. Blood was sampled from venous catheters in the resting and exercising arm at baseline, at the end of exercise, and at 10, 30, 60, and 120 min after exercise. Lactate was significantly elevated in the exercising arm (+276 ± 35%; P < 0.0005) with no change in the resting arm. In contrast, increases in both arms were observed for interleukin-6 (+139 ± 51%; P < 0.0005), growth hormone (+1,104 ± 284%; P < 0.003), natural killer cells (+81 ± 9%; P < 0.0005), and lymphocytes expressing CD62L, CD11a, and CD54. There were no significant differences in these increases between the resting and exercising arm. Catecholamines increased in both arms epinephrine peak increase, +226 ± 36% ( P < 0.001); norepinephrine peak increase, +90 ± 15% ( P < 0.01). Fibroblast growth factor-2 initially decreased with exercise in both arms, and this was followed by a rebound increase. Vascular endothelial growth factor demonstrated a small but significant increase in both arms (+124 ± 31%; P < 0.05). Brief, low-intensity exercise leads to a systemic rather than local response of mediators that could be involved in inflammation, repair, or angiogenic adaptation to physical activity. inflammation single arm white blood cells Footnotes This work was supported by National Institutes of Health Grants MO1-RR-00827, HL-57265, HD 23969, and AG-13332. D. Nemet is a Postdoctoral Research Fellow of the Joseph W. Drown Foundation. Address for reprint requests and other correspondence: D. M. Cooper, Univ. of California Irvine College of Medicine, Clinical Research Center, Bldg. 25, ZOT 4094-03, 101 The City Dr., Orange, CA 92868 (E-mail: dcooper@uci.edu ). The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “ advertisement ” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. April 26, 2002;10.1152/japplphysiol.00035.2002 Copyright © 2002 the American Physiological Society
TI - Systemic vs. local cytokine and leukocyte responses to unilateral wrist flexion exercise
JF - Journal of Applied Physiology
DO - 10.1152/japplphysiol.00035.2002
DA - 2002-08-01
UR - https://www.deepdyve.com/lp/the-american-physiological-society/systemic-vs-local-cytokine-and-leukocyte-responses-to-unilateral-wrist-7h9A4xgalg
SP - 546
VL - 93
IS - 2
DP - DeepDyve
ER -