TY - JOUR
AU - Tang, Yong
AB - Neurosci. Bull. www.neurosci.cn https://doi.org/10.1007/s12264-023-01049-2 www.springer.com/12264 RESEARCH HIGHLIGHT Decoupling SERT‑nNOS Interaction to Generate Fast‑Onset Antidepressants 1 1 1,2 Qing Ye  · Si‑Si Lin  · Henning Ulrich  · 1,3 Yong Tang   Received: 28 November 2022 / Accepted: 24 February 2023 © Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences 2023 Major depressive disorder (MDD) is one of the most com- suppression of NMDARs on active pyramidal neurons in the mon psychiatric disorders, and ~ 4.7% of the world’s popu- neocortex contributes to the dissociated state of the brain. lation has an onset of depression in any one-year period. This dissociative effect and abuse potential have resulted It causes constant distress, impairs social function and in its restriction by regulatory agencies [4–6]. In addition, physiological health, and even leads to suicide [1]. Numer- a recent clinical trial of psilocybin for treatment-resistant ous studies support the classic monoamine hypothesis of depression significantly improved depressive symptoms 24 depressive episodes. The majority of clinical antidepres- h after treatment but induced some adverse events in 77% sants have been developed on the basis of this hypothesis of participants [7]. to increase 5-hydroxytryptamine (5-HT). The selective Recently, a paper published in Science [8] reported that serotonin reuptake 
TI - Decoupling SERT-nNOS Interaction to Generate Fast-Onset Antidepressants
JF - Neuroscience Bulletin
DO - 10.1007/s12264-023-01049-2
DA - 2023-08-01
UR - https://www.deepdyve.com/lp/springer-journals/decoupling-sert-nnos-interaction-to-generate-fast-onset-7eshLid5nv
SP - 1327
EP - 1329
VL - 39
IS - 8
DP - DeepDyve
ER -