TY - JOUR
AU1 - Joshi, Rhythm
AU2 - Garg, Aakriti
AU3 - Khan, Zehva
AU4 - Bhurani, Dinesh
AU5 - Nidhi,
AU6 - Khan, Mohd Ashif
AB - Hematopoietic stem cell transplantation (HSCT) or Bone Marrow Transplantation (BMT) has significantly improved the survival rates of patients suffering from hematological malignancies. However, the cure can only be achieved at the price of morbidity and long-term complications. Thus, this study aimed to evaluate the short-term effect of HSCT on depressive behavior, cognition, and quality of life (QoL) in leukemia patients. Sixty patients were included in this prospective observational study. The current study assessed depression using Patient Health Questionnaire (PHQ-9) scale, cognition using Montreal Cognitive Assessment (MOCA) scale and QoL using European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ C30) before 7 days of the therapy i.e., preconditioning/baseline (TP1) and after 30 days of the treatment (TP2) in leukemia patients undergoing HSCT. At TP2, there was a significant improvement in PHQ-9 (p = 0.001), MOCA (p < 0.0001), functional scale (p < 0.0001) and global health & QoL scale (p = 0.001) of EORTC QLQ C30 scores whereas there was a significant decrease in symptom scale of EORTC QLQ C30 score (p = 0.005). Furthermore, at TP2 a statistically significant (p < 0.05) negative correlation was observed between MOCA and symptom scale of EORTC QLQ C30 after Pearson correlation analysis. In conclusion, post-30 days of HSCT there was alleviation in depressive behavior, cognition, and QoL in leukemia patients compared to before therapy.Graphical abstract[graphic not available: see fulltext]
TI - Short-Term Impact of Hematopoietic Stem Cell Transplantation on Depressive Behavior, Cognition and Quality of Life in Leukemia Patients
JF - Indian Journal of Hematology and Blood Transfusion
DO - 10.1007/s12288-023-01653-2
DA - 2024-01-01
UR - https://www.deepdyve.com/lp/springer-journals/short-term-impact-of-hematopoietic-stem-cell-transplantation-on-7SgZYht02f
SP - 83
EP - 90
VL - 40
IS - 1
DP - DeepDyve
ER -