TY - JOUR
AU - Saito, Hiroshi
AB - A new styrene derivative having an L‐gulonic moiety, N‐(p‐vinylbenzyl)‐6‐L‐gulonamide (VB‐6‐Glco, 3) was synthesized from L‐gulono‐1,4‐lactone and p‐vinylbenzylamine. The styrene derivative (3) was subjected to the radical homopolymerization and copolymerization with acrylamide and acrylic acid. The hydrolysis of p‐nitrophenyl β‐D‐glucuronide with β‐glucuronidase was scarcely inhibited in the presence of the glycopolymer prepared from 3 and acrylamide (P(VB‐6‐Glco‐co‐AAm), 4), whereas the glycopolymer prepared from 3 and acrylic acid (P(VB‐6‐Glco‐co‐AAK), 5) was found to suppress the enzyme activity strongly as well as a polystyrene derivative having pendant D‐glucaric moieties (P(VB‐6‐GlcaH‐co‐AAm), 6). From the kinetic analysis of the hydrolysis, the glycopolymers 6 and 5 were postulated to inhibit the enzyme competitively and uncompetitively, respectively. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 2773–2779, 1999
TI - Glycopolymeric inhibitors of β‐glucuronidase. II. Synthesis of glycopolymers containing pendant L‐gulonic moieties and effects of the carboxyl group in the glycopolymers upon the activity of β‐glucuronidase
JO - Journal of Polymer Science Part A Polymer Chemistry
DO - 10.1002/(SICI)1099-0518(19990801)37:15<2773::AID-POLA11>3.0.CO;2-1
DA - 1999-01-01
UR - https://www.deepdyve.com/lp/wiley/glycopolymeric-inhibitors-of-glucuronidase-ii-synthesis-of-79TKOAl4Jj
SP - 2773
EP - 2779
VL - 37
IS - 15
DP - DeepDyve
ER -