TY - JOUR
AU - Fox, Anthony F, J
AB - Abstract Mechanization of the Bratton and Marshall procedure for the analysis of sulfonamides in biological fluids usually incorporated a dialysis step. Results for sulfamethoxazole and its major metabolite (N4-acetylsulfamethoxazole) by the traditional method of acid hydrolysis often showed "negative" quantities of the metabolite. After an exhaustive examination it was found that the dialysis step must be rigorously controlled and for most laboratory applications it was better to omit the dialysis, when removal of protein and dilution of samples and standards outside the mechanized system was necessary. Reasons for the dialysis omission are discussed. N4-acetylsulfamethoxazole, AutoAnalyzer, effects of dialysis on accuracy This content is only available as a PDF. © 1974 The American Association of Clinical Chemists, Inc. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
TI - Modification of an Automated Method for Measurement of Sulfamethoxazole and Its Major Metabolite in Biological Fluids
JF - Clinical Chemistry
DO - 10.1093/clinchem/20.2.288
DA - 1974-02-01
UR - https://www.deepdyve.com/lp/oxford-university-press/modification-of-an-automated-method-for-measurement-of-74UIsjL2fc
SP - 288
EP - 293
VL - 20
IS - 2
DP - DeepDyve
ER -