TY - JOUR
AU - Assarzadegan, Naziheh
AB - ObjectiveThis study aimed to examine the relationship between low-grade appendiceal mucinous neoplasms (LAMNs) and serrated polyps (SPs) of the appendix, both characterized by KRAS mutations and overlapping morphologic features.MethodsWe analyzed 27 cases of LAMN and 24 cases of SP from archival records, reviewed pathology, and performed molecular analysis on select cases. Four cases initially diagnosed as LAMN were excluded for not meeting diagnostic criteria, and 1 SP case was reclassified as LAMN.ResultsMicroscopic evaluation revealed serrated architecture in 8 (29.6%) of 27 LAMNs: 4 hyperplastic polyp-like, 2 sessile serrated lesion-like (SSL), and 1 traditional serrated adenoma-like (TSA). One case exhibited both SSL- and TSA-like areas. Among SPs, 3 (12.5%) of 24 cases showed morphologic overlap with LAMN due to cytoplasmic mucin, flattened mucosa, and conventional adenoma-like features; all were grossly visible. KRAS was the most common mutation in LAMNs with serrated architecture (4/4, 100%), 1 classic LAMN, and 1 SP with dysplasia and associated signet-ring cell carcinoma.ConclusionsSerrated polyps and LAMNs likely represent a biological continuum, sharing key features such as KRAS mutations and morphologic overlap. Our findings underscore the need for careful molecular and histopathologic evaluation in diagnosing these neoplasms.
TI - Connecting the dots: Low-grade appendiceal mucinous neoplasms and serrated polyps in the appendix
JF - American Journal of Clinical Pathology
DO - 10.1093/ajcp/aqae183
DA - 2025-01-20
UR - https://www.deepdyve.com/lp/oxford-university-press/connecting-the-dots-low-grade-appendiceal-mucinous-neoplasms-and-740V0odbDH
SP - 752
EP - 757
VL - 163
IS - 5
DP - DeepDyve
ER -