TY - JOUR
AU - Geiger, A.
AB - Abstract Pantothenic acid interferes with biotin absorption in non-ruminant species. The objective of this study was to determine whether pantothenic acid affects the concentration of biotin in the blood of young calves. Weaned bull calves (n = 16) were fed ad libitum a pelleted starter including no B-vitamins and hay for 2 wk before the beginning and until the end of the experiment. Water was available ad libitum at all times. Two weeks after weaning, calves were blocked by age and randomly assigned to 4 treatments according to a randomized complete block design. Treatments consisted of administering, for 14 d, a daily gelatin capsule containing no B-vitamins (CON), 10 mg of biotin (Rovimix Biotin; BIO), 240 mg of pantothenic acid (Rovimix Calpan; PAN), and 10 mg biotin + 240 mg pantothenic acid (BIO+PAN). Expeller soybean meal was used as a carrier of the vitamins in the capsules. Blood samples were collected by venipuncture of the jugular vein at Days 0 and 14. Concentrations of avidin-binding substances (ABS) in plasma (1:20 dilution) were determined by a single-step competitive enzyme-binding assay (Ridascreen Biotin kit; R-Biopharm GmbH, Darmstadt, Germany). Statistical analysis was performed using the MIXED procedure of SAS as for a randomized complete block design with repeated measures. The statistical model included the effects of treatment (fixed, df = 3), block (random, df = 3), treatment by block interaction (random, df = 9), time (fixed, df = 1), treatment by time interaction (fixed, df = 3), and the random residual error. The concentrations of ABS in plasma were similar for all treatments (P > 0.24) and did not change after dosing vitamins over time (3.47 and 3.07 ng/mL for Days 0 and 14, respectively; SEM = 0.7 ng/mL; P > 0.63). Plasma concentrations of ABS were substantially higher than those previously reported for lactating dairy cows (0.7–2.1 ng/mL). Based on these data, and contrary to our expectations, pantothenic acid did not affect the absorption of biotin in young calves. PDF This content is only available as a PDF. American Society of Animal Science © American Society of Animal Science 2016
TI - 1661 Pantothenic acid does not affect the concentration of biotin in plasma of Holstein bull calves
JF - Journal of Animal Science
DO - 10.2527/jam2016-1661
DA - 2016-10-01
UR - https://www.deepdyve.com/lp/oxford-university-press/1661-pantothenic-acid-does-not-affect-the-concentration-of-biotin-in-6zL7bAEVBn
SP - 809
EP - 810
VL - 94
IS - suppl_5
DP - DeepDyve
ER -