TY - JOUR
AU - EVANS, HERBERT M.
AB - Abstract IN 1937, MOON reported that the body weight gain of young castrate rats was retarded by the injection of anterior pituitary extracts rich in the adrenocorticotropic factor. There is now conclusive evidence from the injection of the pure hormone (Evans, Li and Simp-son, 1943) that the stunting produced by the cruder extracts was due to this hormone. The present paper reports the characteristic effects of this hormone on chondrogenesis and osteogenesis in the epiphyseal region of the tibia. Twelve male rats 26 days of age were injected intraperitoneally with pure adrenocorticotropic hormone (ACTH) for thirty days thrice daily, the total daily dose being 1 mg. A corresponding number of rats was used as controls. In half the experimental and half the control rats, food consumption was measured. As will be seen in Table 1, the injected rats gained only half as much in body weight as the controls during the experimental period (80 gm. compared with 154 gm.). This content is only available as a PDF. Author notes 1 Aided by grants from the American Foundation for Dental Science, the California State Dental Association, the Research Board of the University of California, the Rockefeller Foundation, New York City and the Josiah Macy, Jr. Foundation. Copyright © 1944 by The Endocrine Society
TI - EFFECTS OF ADRENOCORTICOTROPIC HORMONE (ACTH) ON THE OSSEOUS SYSTEM IN NORMAL RATS
JO - Endocrinology
DO - 10.1210/endo-34-5-305
DA - 1944-05-01
UR - https://www.deepdyve.com/lp/oxford-university-press/effects-of-adrenocorticotropic-hormone-acth-on-the-osseous-system-in-6v5i4djKv0
SP - 305
EP - 310
VL - 34
IS - 5
DP - DeepDyve
ER -