TY - JOUR
AU - Vagnarelli, Paola
AB - Heterochromatin Protein 1 (HP1) is a highly conserved protein that has been used as a classic marker for heterochromatin. HP1 binds to di- and tri-methylated histone H3K9 and regulates heterochromatin formation, functions and structure. Besides the well-established phosphorylation of histone H3 Ser10 that has been shown to modulate HP1 binding to chromatin, several studies have recently highlighted the importance of HP1 post-translational modifications and additional epigenetic features for the modulation of HP1-chromatin binding ability and heterochromatin formation. In this review, we summarize the recent literature of HP1 post-translational modifications that have contributed to understand how heterochromatin is formed, regulated and maintained.
TI - How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance
JO - Cells
DO - 10.3390/cells9061460
DA - 2020-06-12
UR - https://www.deepdyve.com/lp/multidisciplinary-digital-publishing-institute/how-hp1-post-translational-modifications-regulate-heterochromatin-6fWW6Csf7C
VL - 9
IS - 6
DP - DeepDyve
ER -