TY - JOUR
AU - West, Michael D.
AB - Abstract Background: The dramatic alterations in the appearance of the integument with increasing age are due in part to a progressive destruction of the delicate architecture of the connective tissue components of the dermis. Both collagenous and elastic components display a degeneration consistent with the overexpression of proteolytic activity. Recent advances in the field of molecular gerontology, using in vitro models of cellular aging, are yielding clues as to the fundamental causes of dermal aging. Observations: Dermal fibroblasts possess a finite replicative capacity of 50 to 100 doublings, then cease replicating in response to growth factors. Cells cultivated to the end of their replicative lifespan in vitro display alterations consistent with their playing a role in aging in vivo. In particular, senescent dermal fibroblasts overexpress metalloproteinase activities that may explain the age-related atrophy of extracellular matrix architecture. 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TI - The Cellular and Molecular Biology of Skin Aging
JF - Archives of Dermatology
DO - 10.1001/archderm.1994.01690010091014
DA - 1994-01-01
UR - https://www.deepdyve.com/lp/american-medical-association/the-cellular-and-molecular-biology-of-skin-aging-6camoWJoyV
SP - 87
EP - 95
VL - 130
IS - 1
DP - DeepDyve
ER -