TY - JOUR
AU1 - Mårtensson, Johan
AU2 - Bihari, Shailesh
AU3 - Bannard-Smith, Jonathan
AU4 - Glassford, Neil
AU5 - Lloyd-Donald, Patryck
AU6 - Cioccari, Luca
AU7 - Luethi, Nora
AU8 - Tanaka, Aiko
AU9 - Crisman, Marco
AU1 - Rey de Castro, Nicolas
AU1 - Ottochian, Marcus
AU1 - Huang, Agnes
AU1 - Cronhjort, Maria
AU1 - Bersten, Andrew
AU1 - Prakash, Shivesh
AU1 - Bailey, Michael
AU1 - Eastwood, Glenn
AU1 - Bellomo, Rinaldo
AB - Purpose: We set out to assess the resuscitation fluid requirements and physiological and clinical responses of inten‑ sive care unit (ICU) patients resuscitated with 20% albumin versus 4–5% albumin. Methods: We performed a randomised controlled trial in 321 adult patients requiring fluid resuscitation within 48 h of admission to three ICUs in Australia and the UK. Results: The cumulative volume of resuscitation fluid at 48 h (primary outcome) was lower in the 20% albumin group than in the 4–5% albumin group [median difference − 600 ml, 95% confidence interval (CI) − 800 to − 400; P < 0.001]. The 20% albumin group had lower cumulative fluid balance at 48 h (mean difference − 576 ml, 95% CI − 1033 to − 119; P = 0.01). Peak albumin levels were higher but sodium and chloride levels lower in the 20% albumin group. Median (interquartile range) duration of mechanical ventilation was 12.0 h (7.6, 33.1) in the 20% albumin group and 15.3 h (7.7, 58.1) in the 4–5% albumin group (P = 0.13); the proportion of patients commenced on renal replace‑ ment therapy after randomization was 3.3% and 4.2% (P = 0.67), respectively, and the proportion discharged alive from ICU was 
TI - Small volume resuscitation with 20% albumin in intensive care: physiological effects
JF - Intensive Care Medicine
DO - 10.1007/s00134-018-5253-2
DA - 2018-10-21
UR - https://www.deepdyve.com/lp/springer-journals/small-volume-resuscitation-with-20-albumin-in-intensive-care-6T3B07FEvb
SP - 1797
EP - 1806
VL - 44
IS - 11
DP - DeepDyve
ER -