TY - JOUR
AU - Murray, Henry W.
AB - Fifteen Indian patients with relapsing or drug-refractory visceral leishmaniasis were retreated for 30 days with antimony plus interferon-v (IFN- ã). All 15 had failure of an initial course of antimony and at least one additional course of antimony or pentamidine; 7 patients had failure of three or four prior courses of therapy. During the study, treatment was discontinued in 2 patients because of anemia and congestive heart failure in 1 and intractable vomiting in the other; both subsequently died. In the remaining 13 patients, IFN-ã plus antimony treatment was associated with daily fever but no other adverse reactions. After 30 days of therapy, 9 (69%) of the 13 patients were apparently cured. Six months after treatment, all 9 were healthy, had parasite-free bone marrow aspirate smears, and were considered cured. None have relapsed during a mean follow-up of 15.9 ± 1.7 months. These results support the use of antimony plus IFN-ã as an immunochemotherapeutic alternative for kala-azar patients who have repeated failures of conventional treatment.
TI - Successful Treatment Of Refractory Visceral Leishmaniasis In India Using Antimony Plus Interferon-ã
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/170.3.659
DA - 1994-09-01
UR - https://www.deepdyve.com/lp/oxford-university-press/successful-treatment-of-refractory-visceral-leishmaniasis-in-india-6QnuQd0VsB
SP - 659
EP - 662
VL - 170
IS - 3
DP - DeepDyve
ER -