TY - JOUR
AB - Volume 43 Issue 11 June 2022 Electrophoresis 43 (11) 1121–1248 Front Cover: Evaluation of an icIEF-MS system for comparable charge variant analysis of biotherapeutics with rapid peak identification by mass spectrometry Xiaoping He, Mariam ElNaggar, Maggie A. Ostrowski, Andras Guttman, Erik Gentalen, and Justin Sperry DOI: 10.1002/elps.202100295 The cover picture shows a microfluidic chip-based integrated icIEF-MS technology for char- acterizing monoclonal antibodies. Antibody charge variants are color-coded and correspond to acidic and basic modifications. Charge variants are separated by pI, mobilized toward the on-chip electrospray tip, ionized, and detected using mass spectrometry. Identification of an- tibody modifications is achieved using accurate mass and abundance patterns observed in proteoform distributions. Back Cover: The comparison between 2DE-MS and bottom-up LC-MS demands high-end techniques for both technologies Xianquan Zhan and Peter R. Jungblut DOI: 10.1002/elps.202200036 The cover picture shows meta-analysis in proteomics: how is bottom-up liquid chromatography-mass spectrometry (BU-LC-MS) compared with two-dimensional gel electrophoresis-mass spectrometry (2DE-MS)? If oranges (BU-LC-MS) growing in the Mediterranean area (high-sensitivity MS) are compared with apples (2DE-MS) growing in the desert (low-sensitivity MS), one will find that the oranges are larger (lower number of multiprotein species proteins) than the apples (higher number of multiprotein species proteins). However, this 
TI - Contents: Electrophoresis 11'22
JF - Electrophoresis
DO - 10.1002/elps.202270063
DA - 2022-06-01
UR - https://www.deepdyve.com/lp/wiley/contents-electrophoresis-11-22-6ML0VOCyue
SP - 1124
EP - 1126
VL - 43
IS - 11
DP - DeepDyve
ER -