TY - JOUR
AU - 
AB - A vast array of thiazole derivatives having excellent broad spectrum activity forms an invaluable part of the present armory of the clinicians. The synthesis and antibacterial activity of several 5 nd new ethyl 2-amino-4-methylthiazole-5-carboxylate(1) derivatives substituted at 2 position by aryl aldehydes of the thiazole moiety have shown some to increase the antibacterial activity of thiazole. In this study we thought to synthesize thiazole system incorporating substituted aryl aldehydes. The most active compound was 4-methyl-5-hydrazine hydrate-2-(4-methoxy-3- hydroxy benzene) methyleneamino thiazole-5-carboxylate (3c) equipotent to Ciprofloxacin.C position of thiazole ring requires large hydrophilic, electronegative functional moieties like substituted phenyl ring etc for enhanced antibacterial activity of thiazole. In our compounds alkyl (methyl) group is present, still most of the compounds show good antibacterial activity.C position of thiazole ring requires small hydrophobic, electronegative functional moieties like amino, hydrazine hydrate attach with ester for antibacterial activity of thiazole in general. Keywords: Thiazole, Aryl aldehydes, 3c, Antibacterial activity. INTRODUCTION Research over the past 50 years has been focused on meeting medical needs to treat infectious disease caused by life threatening pathogens. In spite of the introduction of a variety of antibacterial agents in multiple unrelated drug classes, resistance continues to emerge. The pharmaceutical field 
TI - Synthesis and Evaluation of Novel Thiazole Derivatives
JO - Proceedings of The 14th International Electronic Conference on Synthetic Organic Chemistry
DO - 10.3390/ecsoc-14-00397
DA - 2010-10-31
UR - https://www.deepdyve.com/lp/unpaywall/synthesis-and-evaluation-of-novel-thiazole-derivatives-6Eq0UIWsR9
DP - DeepDyve
ER -